Watkins, B., Schultheiß, J., Rafuna, A., Hintze, S., Meinke, P., Schoser, B. and Kröger, S. (2023) Degeneration of muscle spindles in a murine model of Pompe disease. Scientific Reports13: 6555; DOI: 10.1038/s41598-023-33543-y
Bornstein, B., Watkins, B., Passini, F.S., Blecher, R., Assaraf, E., Sui, X.M., Brumfeld, V., Tsoory, M., Kröger, S. and Zelzer, E. (2023). The mechanosensitive ion channel ASIC2 mediates both proprioceptive sensing and spinal alignment. Experimental Physiology DOI: 10.1113/EP090776
2022
Watkins, B., Schuster, H.M., Gerwin, L., Schoser, B. and Kröger, S. (2022) The effect of methocarbamol and mexiletine on murine muscle spindle function. Muscle Nerve66: 96-105.
Jacquier, A., Risson, V., Simonet, T., Roussange, F., Lacoste, N., Ribault, S., Carras, J., Theuriet, J., Girard, E., Grosjean, I., Le Goff, L., Kröger, S., Meltoranta, J., Bauche, S., Sternberg, D., Fournier, E., Kostera-Pruszczyk, A., O'Connor, E., Eymard, B., Lochmüller, H., Martinat, C. and Schaeffer, L. (2022) Severe congenital myasthenic syndromes caused by agrin mutations affecting secretion by motoneurons. Acta Neuropathologica144: 707-731.
2021
Doppler, K., Hemprich, A., Haarmann, A., Brecht, I., Franke, M., Kröger, S., Villmann, C. and Sommer, C. (2021) Autoantibodies to cortactin and agrin in sera of patients with myasthenia gravis. Journal of Neuroimmunology356: 577588.
Kröger S. and Watkins B. (2021) Muscle spindle function in healthy and diseased muscle.Skeletal Muscle11: 3.
Zhang Y., Otto P., Qin L., Eiber N., Hashemolhosseini S., Kröger S. and Brinkmeier H. (2021) Methocarbamol blocks muscular Nav 1.4 channels and decreases isometric force of mouse muscles. Muscle & Nerve63: 141-150.
2020
Gerwin, L.,
Rossmanith, S., Haupt, C., Schultheiß, J., Brinkmeier,
H., Bittner, R.E. and Kröger,
S. (2020) Impaired
muscle spindle
function in murine models of muscular dystrophy. The
Journal of Physiology 598:1591-1609.
2019
Gerwin, L.,
Haupt, C., Wilkinson, K.A., and Kröger, S. (2019).
Acetylcholine receptors in the equatorial region of
intrafusal muscle fibres modulate mouse muscle spindle
sensitivity. The Journal of Physiology597:
1993-2006.
Handara, G., and
Kröger, S. (2019). Alternative splicing and the
intracellular domain mediate TM-agrin's ability to
differentially regulate the density of excitatory and
inhibitory synapse-like specializations in developing
CNS neurons. Neuroscience419:
60-71.
Handara, G.,
Hetsch, F. J. A., Jüttner, R., Schick, A., Haupt, C.,
Rathjen, F. G., and Kröger, S. (2019) The role of agrin,
Lrp4 and MuSK during dendritic arborization and
synaptogenesis in cultured embryonic CNS neurons. Developmenal
Biology445: 54-67.
2018
Kröger, S.
(2018) Proprioception 2.0: novel functions for muscle
spindles. Current Opinion in Neurology31:
592-598.
2017
Karakatsani,
A., Marichal, N., Urban, S., Kalamakis, G., Ghanem, A.,
Schick, A., Zhang, Y., Conzelmann, K. K., Ruegg, M. A.,
Berninger, B., Ruiz de Almodovar, C., Gascon, S., and
Kröger, S. (2017) Neuronal LRP4 regulates synapse
formation in the developing CNS. Development144:
4604-4615.
Schmidt, N.,
Basu, S., Kröger, S., and Brenner, H. R. (2017) A Cell
Culture System to Investigate the Presynaptic Control of
Subsynaptic Membrane Differentiation at the Neuromuscular
Junction. Methods in Molecular Biology 1538, 3-11.
2016
Schneider, S., Gruart, A.,
Grade, S., Zhang, Y., Kröger, S., Kirchhoff, F., Eichele,
G., Delgado Garcia, J. M., and Dimou, L. (2016) Decrease
in newly generated oligodendrocytes leads to motor
dysfunctions and changed myelin structures that can be
rescued by transplanted cells. Glia64:
2201-2218.
2015
Zhang Y., Lin S.,
Karakatsani A., Rüegg M., Kröger S. (2015) Differential
regulation of AChR clustering in the polar and equatorial
region of murine muscle spindles. European Journal of
Neuroscience41: 69-78.
2014
Gasperi C., Melms A.,
Schoser B., Zhang Y., Meltoranta J., Risson V., Schaeffer
L., Schalke B., Kröger S. (2014) Anti-Agrin Autoantibodies
in Myasthenia gravis. Neurology82:
1976-1983.
Zhang Y., Wesolowska M.,
Karakatsani A., Wizemann V., Kröger S. (2014) Formation of
cholinergic synapse-like specializations at developing
murine muscle spindles. Developmental Biology393:
227-235.
Steiner E., Enzmann G.U.,
Lyck R., Lin S., Rüegg M.A., Kröger S., Engelhardt B.
(2014) The heparan sulfate proteoglycan agrin contributes
to barrier properties of mouse brain endothelial cells by
stabilizing adherens junctions. Cell and Tissue
Research358: 465-479.
2013
Choi, H.Y., Liu, Y.,
Tennert, C., Sugiura, Y., Karakatsani, A., Kröger, S.,
Johnson, E.B., Hammer, R.E., Lin, W., Herz, J., (2013) APP
interacts with LRP4 and agrin to coordinate the
development of the neuromuscular junction in mice. Elife20: 2:e00220. doi: 10.755/eLife.00220.
2012
Pevzner, A., Schoser,
B.,Peters, K., Cosma, N.C., Karakatsani, A., Schalke, B.,
Melms, A., and Kröger, S. (2012). Anti-LRP4 autoantibodies
in AChR- and MuSK-antibody-negative myasthenia gravis. Journal
of Neurology259: 427-435.
Burk, K., Desoeuvre, A.,
Boutin, C., Smith, M.A., Kröger, S., Bosio, A., Tiveron,
M.C., and Cremer, H. (2012). Agrin-signaling is necessary
for the integration of newly generated neurons in the
adult olfactory bulb. Journal of Neuroscience32:
3759-3764.
2010
Patzke C., Max K.E.A.,
Behlke J., Schreiber J., Schmidt H., Dorner A., Kröger S.,
Henning M., Otto A., Heinemann U., and Rathjen F.G. (2010)
The coxsackievirus-adenovirus receptor reveals complex
homophilic and heterophilic interactions on neural cells.
Journal of Neuroscience 30: 2897-2910.
Porten E., Seliger B., Schneider V.A., Wöll S.,
Stangel D., Ramseger R., and Kröger S. (2010) The
process-inducing activity of transmemgrane agrin
requires follistatin-like domains. The Journal of
Biological Chemistry285:3114-3125.
2009
Kröger,S. and Pfister,H.
(2009) Agrin in the nervous system - synaptogenesis and
beyond. Future Neurology4:
67-86
Ramseger,R., White,R., and
Kröger,S. (2009) Transmembrane form agrin-induced process
formation requires lipid rafts and the activation of Fyn
and MAPK. The Journal of Biological Chemistry284:
7697-7705.
Jimenez-Mallebrera C.,
Torelli S., Feng L., Kim J., Godfrey C., Clement E., Mein
R., Abbs S., Brown S.C., Campbell K.P., Kröger S., Talim
B., Topaloglu H., Quinlivan R., Roper H., Childs A.M.,
Kinali M., Sewry C.A., and Muntoni F. (2009) A comparative
study of alpha-dystroglycan glycosylation in
dystroglycanopathies suggests that the hypoglycosylation
of alpha-dystroglycan does not consistently correlate with
clinical severity. Brain Pathology19:
596-611.
2008
Yamamoto,T.; Kato,Y.;
Kawaguchi-Niida,M.; Shibata,N.; Osawa,M.; Saito,K.;
Kröger,S.; and Kobayashi,M. (2008) Characteristics of
neurons and glia in the brain of Fukuyama type congenital
muscular dystrophy. Acta Myologica 27:
9-13
2007
Schröder, J.E.; Tegeler,
M.; Großhans, U.; Porten, E.; Blank, M.; Lee, J.; Esapa,
C.; Blake, D.J., and Kröger, S. (2007) Dystroglycan
regulates structure, proliferation and differentiation of
neuroepithelial cells in the developing vertebrate CNS. Developmental
Biology307: 62-78
Noell, S., Fallier-Becker,
P., Becker, C., Kröger, S., Mack, A.F., and Wolburg, H.
(2007) Effects of agrin on the expression and distribution
of the water channel protein aquaporin-4 and volume
regulation in cultured astrocytes. European Journal
of Neuroscience26: 2109-2118
2006
Annies,
M., Bittcher, G., Ramseger, R., Löschinger, J., Wöll,
S., Porten, E., Abraham, C., Rüegg, M.A., and Kröger, S.
(2006) Clustering of transmembrane-agrin induces
filopodia-like processes on axons and dendrites. Molecular
and Cellular Neuroscience 31:
515-524.
Jastrow.
H., Koulen, P., Altrock, W.D., and Kröger, S. (2006)
Identification of a b-dystroglycan
immunoreactive sub-compartment in photoreceptor
terminals. Investigative Ophthalmology and Visual
Science 47: 17-24.
2005
Saito, F., Blank, M.,
Schröder, J., M anya, H., Shimizu, T., Campbell, K.P.,
Endo, T., Mizutani, M., Kröger, S. , and Matsumura, M.
(2005) Aberrant glycosylation of a-dystroglycan
causes defective binding of laminin in the muscle of
chicken muscular dystrophy. FEBS Letters 579:
2359-2363 .
Schnepp
A., Lindgren P., Hülsmann H., Kröger S, Paulsson M., and
Hartmann U. (2005) Mouse testican-2: Expression,
glycosylation and effects on neurite outgrowth. Journal
of Biological Chemistry 280:
11274-11280.
2004
Saito, F., Blank, M.,
Schröder, J., Manya, H., Shimizu, T., Campbell, K.P.,
Endo, T., Mizutani, M., Kröger, S., and Matsumura, K.
(2004) Aberrant glycosylation and defective
laminin-binding of alpha-dystroglycan in chicken muscular
dystrophy. Neuromuscular Disorders 14:
603-604.
Brown, S.C.,
Torelli, S., Brockington, M., Yuva, Y., Jimenez, C., Feng,
L., Anderson, L., Ugo, I., Kröger, S., Bushby, K., Voit,
T., Sewry, C., and Muntoni, F. (2004) Abnormalities in a-Dystroglycan Expression in MDC1C
and LGMD2I Muscular Dystrophies. American Journal of
Pathology164: 727-737.
Warth A.,
Kröger, S., and Wolburg, H. (2004) Loss of agrin
immunoreactivity from brain capillary basal laminae
correlates with the redistribution of aquaporin-4 in human
glioblastoma multiforme. Acta Neuropathologica
207: 311-318.
Herzog, C.,
Has, C., Franzke, C.-W., Echtermeyer, F.G., Kröger, S.,
Gustafsson, E., Fässler, R., and Bruckner-Tuderman, L.
(2004) Dystroglycan in skin and cutaneous cells: b-subunit is shed from the cell
surface. Journal of Investigative Dermatology 122:
1372-1380.
2003
Esapa, C.T.,
Bentham, G.R.B., Schröder, J.E., Kröger, S., and Blake,
D.J. (2003) The effects of post-translational processing
on dystroglycan synthesis and trafficking. FEBS
Letters, 555: 209-216.
2002
Annies, M.,
and Kröger, S. (2002) Isoform pattern and AChR aggregation
activity of agrin expressed by embryonic chick retinal
ganglion neurons. Molecular and Cellular Neuroscience20: 525-535.
Esapa, C. T.,
Benson M. A., Schröder, J. E., Martin-Rendon, E.,
Brockington, M., Brown, S.C., Muntoni, F., Kröger, S., and
Blake, D.J. (2002) Functional requirements for
fukutin-related protein in the Golgi apparatus. Human
Molecular Genetics11: 3319-3331.
Kröger, S., and Schröder,
J. E. (2002) Agrin in the CNS: New roles for a synapse
organizer. News in Physiological Science17:
207-212.
Rascher, G., Fischmann,
A., Kröger, S., Duffner, F., Grote, E. H., and Wolburg, H.
(2002) Extracellular matrix and the blood-brain barrier in
glioblastoma multiforme: spatial segregation of tenascin
and agrin. Acta Neuropathologica, 104:
85-91.
Blank,
M., Blake, D.J. uand Kröger, S. (2002) Molecular
heterogeneity of dystrophin-like complexes in the
developing and adult retina. Neuroscience, 111:
259-273.
Kröger, S.
(2002) Agrin: ein Hauptregulator der Synapsenbildung. BIOforum12: 49-51
2001
Kröger, S. (2001)
Extracellular signals regulating nervous system
development. In: The Neurosciences at the Turn of the
Century. Seite 669-672; Ed. N. Elsner und G. W.
Kreutzberg; Thieme Verlag Stuttgart
Neumann F.R., Bittcher,
G., Annies, M. Schumacher, B. Kröger, S., and Ruegg, M.A.
(2001) An alternative amino-terminus expressed in the
central nervous system converts agrin to a type II
transmembrane protein. Molecular and Cellular
Neuroscience17: 208-225.
Yard, B. A.,
Kahlert, S., Engelleiter, R., Resch, S., Waldherr, R.,
Groffen, A. J., van den Heuvel, L. P. W. J., van der Born,
J., Berden, J. H. M., Kröger, S., Hafner, M., and van der
Woude, F. J. (2001). Decreased glomerular expression of
agrin in diabetic nephropathy and podocytes, cultured in
high glucose medium. Experimental Nephrology9:
214-222.
Schröder,
J.E., Tegeler, M., and Kröger, S. (2001) Die molekulare
Grundlage von Muskeldystrophien. BioForum11:
2-4.
2000
Blake, D.J., and Kröger,
S. (2000) The neurobiology of Duchenne Muscular Dystrophy:
learning lessons from muscle? Trends in Neurosciences23: 92-99.
Herrmann, R., Straub V.,
Blank, M., Kutzick, C., Franke, N., Neuen Jacob, E.,
Lenard, H.-G., Kröger, S., and Voit, T. (2000)
Dissociation of the dystroglycan-complex in
caveolin-3-deficient Limb Girdle Muscular Dystrophy. Human
Molecular Genetics9: 2335-2340.
1999
Hering, H. and Kröger, S.
(1999) Synapse formation and agrin expression in
stratospheroid cultures from embryonic chick retina. Developmental
Biology214: 412-428.
Koulen, P., Honig, L.S.,
Fletcher, E.L. and Kröger, S. (1999) Expression,
distribution, and ultrastructural localization of the
synapse-organizing molecule agrin in the mature avian
retina. European Journal of Neuroscience11:
4188-4196.
Blank, M., Koulen, P.,
Blake, D., and Kröger, S. (1999) Dystrophin and
beta-dystroglycan in photoreceptor terminals from normal
and mdx3Cv mouse retinae. European
Journal of Neuroscience11: 2121-2133.
1998
Koulen, P., Blank, M., and
Kröger, S. (1998) Differential distribution of b-dystroglycan in rabbit and rat
retina. Journal of Neuroscience Research51:
735-747.
1997
Kröger, S. (1997)
Differential distribution of agrin isoforms in the
developing and adult avian retina. Molecular and
Cellular Neuroscience10: 149-161.
Blank, M.,
Koulen, P., and Kröger, S. (1997) Subcellular
concentration of b-dystroglycan
in photoreceptor terminals and Müller glial cells of the
chick retina. Journal of Comparative Neurology389:
668-678.
Galarraga, E., and Kröger,
S. (1997) Connections between neuroscientists from Europe
and Latin America reinforced. Trends in Neurosciences20: 549-551.
Sorokin, L.
M., Pausch, F., Frieser, M., Kröger, S., Ohage, E., and
Deutzmann, R. (1997) Developmental regulation of the
laminin a5 chain suggests a
role in epithelial and endothelial cell maturation. Developmental
Biology189: 285-300.
Kröger, S. (1997)
Molecular determinants involved in nervous system
development. In: From Membrane to Mind. Seite
430-433; N. Elsner und H. Wässle; Thieme Verlag,
Stuttgart.
Reiss, Y., Layer, P. G.,
and Kröger, S. (1997) Butyrylcholinesterase-positive cells
of the developing chicken retina that are noncholinergic
and GABA positive. Developmental Brain Research100:
62-72.
Koulen, P., Brandtstätter,
J. H., Kröger, S., Enz, R., Bormann, J., and Wässle, H.
(1997) Immunocytochemical localization of the GABAC
receptor r-subunits in the
cat, goldfish and chicken retina. Journal of
Comparative Neurology380: 520-532.
1996
Mann, S., and Kröger, S.
(1996) Agrin is synthesized by retinal cells and
colocalizes with gephyrin. Molecular and Cellular
Neuroscience8: 1-13.
Hering, H.,
and Kröger, S. (1996) Formation of synaptic
specializations in the inner plexiform layer of the
developing chick retina. Journal of Comparative
Neurology375: 393-405.
Reiss, Y., Kröger, S.,
Grassi, J., Tsim, K.W.K., Willbold, E., and Layer, P.G.
(1996) Extracellular and asymmetric forms of
acetylcholinesterase are expressed on cholinergic and
non-cholinergic terminal neuropil of the developing chick
retina. Cell and Tissue Research286:
13-22.
Jones, G., Herczeg, A.,
Ruegg, M.A., Lichtsteiner, M., Kröger, S., and Brenner,
H.R. (1996) Substrate-bound agrin induces expression of
acetylcholine receptor e-subunit
gene in cultured mammalian muscle cells. Proceedings
of the National Academy of Science (USA)93:
5985-5990.
Kröger, S., and Mann, S.
(1996) Biochemical and functional characterization of
basal lamina-bound agrin in the central nervous system. European
Journal of Neuroscience8: 500-509.
Kirsch, J.,
and Kröger, S. (1996) Postsynaptic anchoring of receptors:
A cellular approach to neuronal and muscular sensitivity.
The Neuroscientist2: 100-108.
Kröger, S.,
Horton, S.E., and Honig, L.S. (1996) The developing avian
retina expresses agrin isoforms during development. Journal
of Neurobiology29: 165-182.
1995
Tsen, G. Halfter, W.
Kröger, S., and Cole, G.J. (1995) Agrin is a heparan
sulfate proteoglycan. Journal of Biological Chemistry270: 3392-3399.
1992
McMahan, U.J., Horton,
S.E., Werle, M.J., Honig, L.S., Kröger, S., Ruegg, M.A.,
and Escher, G. (1992) Agrin isoforms and their role in
synaptogenesis. Current Oppinion in Cell Biology4:
869-874.
Ruegg, M.A., Tsim, K.W.K.,
Horton, S.E., Kröger, S., und McMahan, U.J. (1992) The
agrin gene codes for a family of basal lamina proteins
that differ in function and distribution. Neuron8:
691-699.
Tsim, K.W.K.,
Ruegg, M.A., Escher, G., Kröger, S., and McMahan, U.J.
(1992). cDNA that encodes active agrin. Neuron8:
677-689.
1991
Kröger, S.,
and Walter, J. (1991). Molecular mechanisms separating two
axonal pathways during development of the avian optic
tectum. Neuron6: 291-303.
1990
Kröger, S., and Schwarz,
U. (1990). The avian tectobulbar tract: Development,
explant culture, and effects of antibodies on the pattern
of neurite outgrowth. Journal of Neuroscience10:
3118-3134.
Kröger, S., and
Niehörster, L. (1990). Isolation, characterization and
substrate properties of the external limiting membrane
from the avian embryonic optic tectum. Journal of
Neuroscience Research27: 169-183.
1987
Halfter, W., Reckhaus, W.,
and Kröger, S. (1987). Nondirected axonal growth on basal
lamina from avian embryonic retina. Journal of
Neuroscience7: 3712-3722.
