Several projects are currently investigated in my lab: We analyze the function of agrin in the developing and the adult central nervous system and we investigate the structure and function of muscle spindles in wildtype and genetically altered mice.
|What are the molecular mechanisms which regulate the formation of synapses in the developing CNS, and do these mechanisms also play a role in the adult brain, for example during plastic changes of synapses in processes like learning and memory?|
|Does the extracellular matrix molecule agrin play a role in the CNS which is similar to its role at the neuromuscular junction? Is agrin also a key-regulator of synapse formation alsoin the developing and adult CNS?|
|What role does the agrin receptor complex play during CNS development as well as in the adult brain?|
|How du muscle spindles function and how are they altered in transgenic mice, in particular in models of neuromuscular disorders?|